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Cytosine-ß-D-arabinofuranoside hydrochloride
Key Features and Details
Cytosine-?-D-Arabinofuranoside Hydrochloride
SYNONYMS: AraC; Arabinosylcytosine; 1-ß-D-Arabinofuranosylcytosine; Cytabarine; Cytosine 1-(ß-D-Arabinofuranosyl)cytosine hydrochloride; Ara-C hydrochloride; Arabinocytidine hydrochloride; Arabinosylcytosine hydrochloride; Cytarabine hydrochloride; Cytosine arabinoside hydrochloride; Cylocide; Cytosar Hydrochloride; Iretin; Spongocytidine Hydrochloride
CAS: #
69-74-9
MOLECULAR FORMULA: C9H13N3O5 HCl
MOLECULAR WEIGHT: 279.677 g/mol
EC No: 200-713-9
MDL No: MFCD00012839
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PRODUCT DESCRIPTION
Cytosine-?-D-Arabinofuranoside Hydrochloride
Application Notes
It is used as an antineoplastic and antiviral agent.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Selective inhibitor of DNA synthesis
SPECIFICATIONS
SKU: 02100071-CF
Base Catalog Number: 100071
Alternate Names: AraC; Arabinosylcytosine; 1-ß-D-Arabinofuranosylcytosine; Cytabarine; Cytosine 1-(ß-D-Arabinofuranosyl)cytosine hydrochloride; Ara-C hydrochloride; Arabinocytidine hydrochloride; Arabinosylcytosine hydrochloride; Cytarabine hydrochloride; Cytosine arabinoside hydrochloride; Cylocide; Cytosar Hydrochloride; Iretin; Spongocytidine Hydrochloride
Biochemical Physiological Actions
: Ara-C is phosphorylated to Ara-CTP and is incorporatee into DNA. It inhibits DNA replication by forming cleavage complexes with topoisomerase I resulting in DNA fragmentation, and ultimately induces apoptosis via the PKC signaling pathway. Does not inhibit RNA synthesis. Anti-leukemia agent.
CAS
: #
69-74-9
EC No
: 200-713-9
Format
: Powder
Hazard Statements
: H317-H319-H341-H361
MDL No
: MFCD00012839
Melting Point
: 356 to 360° F (NTP, 1992)
Molecular Formula
: C9H13N3O5 HCl
Molecular Weight
: 279.677 g/mol
RTECS No
: HA5500000
Safety Symbol
: GHS07, GHS08
Solubility
: >42 [ug/mL]
UV Visible Absorbance
: ?max (water) 280 ± 6 nm
Vapor Pressure
: 8.74X10-12 mm Hg at 25 deg C (est)
