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Tunicamycin
Key Features and Details
Tunicamycin
CAS: #
11089-65-9
MOLECULAR WEIGHT: 816.899 g/mol
BEILSTEIN REGISTRY No.: 6888090
MDL No: MFCD00065709
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PRODUCT DESCRIPTION
Tunicamycin
Application Notes
Tunicamycin has been used to study the effect of N-linked glycosylation of human proton-coupled folate transporter (HsPCFT) in HeLa cells[7]. Tunicamycin has also been used to study the functional effects of coxsackievirus and adenovirus receptor (CAR) glycosylation in COS-7 cells.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Antibiotic | Study of microbial biosynthetic mechanisms
SPECIFICATIONS
SKU: 02150028-CF
Base Catalog Number: 150028
Beilstein Registration No
: 6888090
Biochemical Physiological Actions
: Tunicamycin inhibits many biochemical functions such as synthesis of glycoproteins, procollagen, and peptidoglycans; and IgA and IgE secretion by plasma cells. Blocks the formation of protein N-glycosidic linkages by inhibiting the transfer of N-acetylglucosamine 1-phosphate to dolichol monophosphate. Inhibits bacterial and eukaryote N-acetylglucosamine transferases and prevents formation of N-acetylglucosamine lipid intermediates. Inhibits the expression of functional thrombin receptors on human T-lymphoblastoid cells. Also inhibits thrombin-induced Ca2+ mobilization in cells. Also affects the fibroblast interferon-cell system.
CAS
: #
11089-65-9
Format
: Powder
Hazard Statements
: H300
MDL No
: MFCD00065709
Molecular Weight
: 816.899 g/mol
PPE
: Eyeshields, Faceshields, full-face particle respirator, Gloves, respirator cartridge, respirator filter
RTECS No
: YO7980200
Safety Symbol
: GHS06
Source
: Streptomyces sp.
