No products in the cart.
ß2-Microglobulin, 500 µg
Key Features and Details
ß2-Microglobulin
SYNONYMS: ß2-Microglobulin; ß2-M
CAS: #
Not applicable
MDL No: MFCD00130615
You need to register an account with us
to be able to place an order, Click to Register.
PRODUCT DESCRIPTION
ß2-Microglobulin
Application Notes
To study the effect of ß2 microglobulin , mice models deficient for the ß2 microglobulin gene have been engineered. These mice demonstrate that ß2 microglobulin is necessary for cell surface expression of MHC class I and stability of the peptide binding groove.In the absence of ß2 microglobulin, very limited amounts of MHC class I (classical and non-classical) molecules can be detected on the surface whereas in the absence of MHC class I, CD8 T cells cannot develop. Low levels of ß2 microglobulin can indicate non-progression of HIV.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Stability of the MHC antigens
SPECIFICATIONS
SKU: 02153903.5
Base Catalog Number: 153903.5
Alternate Names: ß2-Microglobulin; ß2-M
Biochemical Physiological Actions
: A transient complex of MHC heavy chain and ß2-Microglobulin is known to be assembled into the TAP molecule (transporter associated with antigen processing) through interactions with a number of chaperones. Binding of processed peptide releases the Class I-ß2-Microglobulin complex to the cell surface. Absence of binding leads to degradation in the proteasome.
CAS
: #
Not applicable
Format
: Solid
Formulation Details
: Lyophilized from 0.02 M NH4(HCO3)
MDL No
: MFCD00130615
Purity
: 30 - 60 %
Source
: Human Urine
