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Aldehyde dehydrogenase
Key Features and Details
From yeast
SYNONYMS: Aldehyde:NAD[P]+ oxidoreductase; ALDH
CAS: #
9028-86-8
EC No: 232-845-3
MDL No: MFCD00081306
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PRODUCT DESCRIPTION
Aldehyde Dehydrogenase
Application Notes
Aldehyde dehydrogenase oxidizes a number of aliphatic and aromatic aldehydes. Acetyl-GSH is not hydrolyzed.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Acting on aldehydes or oxo groups
SPECIFICATIONS
SKU: 02190679-CF
Base Catalog Number: 190679
Alternate Names: Aldehyde:NAD[P]+ oxidoreductase; ALDH
Biochemical Physiological Actions
: Aldehyde dehydrogenase is a tetramer and has several different isoforms. The enzyme tested in 0.01 M pyrophosphate buffer shows a sharp optimum around pH 9.3 with acetaldehyde as substrate. Potassium ions and cysteine are essential for the enzyme's activity. Rubidium or NH4+ can be substituted for K+, and glutathione for cysteine. Lithium, Na+, and Cs+ inhibit the reaction. Aldehyde dehydrogenase is inhibited by propylurea, crotonaldehyde, n-propyl isocyanate, cyclohexyl isocyanate, 1-n-propyl-1-[(4-chlorophenyl)sulphonyl]-3-n-propylurea, and 1-methyl-1-[(4-chlorophenyl)sulphonyl]-3-n-propylurea. The enzyme may be utilized to quantitate aldehydes present in blood.
CAS
: #
9028-86-8
EC No
: 232-845-3
Extinction Coefficient
: 9.4 (279 nm)(Lit)
Format
: Freeze dried stabilized powder, Potassium Activated
MDL No
: MFCD00081306
PPE
: Eyeshields, Gloves, respirator filter
Source
: Yeast
Specific Activity
: Protein-~5 u/mg, solid-=1 u/mg solid
Unit Definition
: One unit causes the oxidation of one µ mole of acetaldehyde to acetic acid per minute at pH 8.0 and 25 °C in the presence of potassium ions and thiols.
