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5-Azacytidine
Key Features and Details
5-Azacytidine
SYNONYMS: 4-Amino-1-(ß-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one; 5-Azacitidine; Ladakamycin
CAS: #
320-67-2
MOLECULAR FORMULA: C8H12N4O5
MOLECULAR WEIGHT: 244.207 g/mol
BEILSTEIN REGISTRY No.: 620461
EC No: 206-280-2
MDL No: MFCD00006539
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PRODUCT DESCRIPTION
5-Azacytidine
Application Notes
5-Azacytidine, its incorporation into RNA alters RNA synthesis and processing, and results in inhibition of protein synthesis. It has been used as a cancer chemotherapeutic agent. It is a powerful bacteriostatic, antitumor, and mutagenic agent; it also exhibits immunosuppressive, antimitotic, radioprotective, and virostatic effects.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Inhibition of protein synthesis | bacteriostatic | antitumor | mutagenic agent
SPECIFICATIONS
SKU: 02100821-CF
Base Catalog Number: 100821
Alternate Names: 4-Amino-1-(ß-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one; 5-Azacitidine; Ladakamycin
Beilstein Registration No
: 620461
Biochemical Physiological Actions
: A potent growth inhibitor and cytotoxic agent; inhibits DNA methyltransferase, an important regulatory mechanism of gene expression, gene activation and silencing. Causes DNA demethylation or hemi-demethylation, creating openings that allow transcription factors to bind to DNA and reactivate tumor suppressor genes
CAS
: #
320-67-2
EC No
: 206-280-2
Format
: Powder
Hazard Statements
: H302-H350
MDL No
: MFCD00006539
Melting Point
: 442 to 446° F (decomposes) (NTP, 1992)
Molecular Formula
: C8H12N4O5
Molecular Weight
: 244.207 g/mol
PPE
: Eyeshields, full-face particle respirator , Gloves, respirator cartridge, respirator filter
RTECS No
: XZ3017500
Safety Symbol
: GHS07, GHS08
Solubility
: >36.6 [ug/mL]
