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Amikacin, phytopure
Key Features and Details
Number: 35717-28-5
SYNONYMS: 1-N-[L(-)-4-Amino-2-hydroxy-butyryl] kanamycin A; O-3-Amino-3-deoxy-a -D-glucopyranosyl-(1 ---> 6)-O-6-amino-6-deoxy-a-D-glucopyranosyl-(1 ---> 4)]- N1 -(4-amino-2-hydroxy-1-oxobutyl)-2-deoxy-D-streptamine; Lukadin
CAS: #
37517-28-5
MOLECULAR FORMULA: C
22
H
43
N
5
O
13
MOLECULAR WEIGHT: 585.60
BEILSTEIN REGISTRY No.: 1445422
EC No: 253-538-5
MDL No: MFCD11045969
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PRODUCT DESCRIPTION
From Kanamycin A. An amino-glycoside antibiotic that works by binding to the bacterial 30S ribosomal subunit, causing misreading of mRNA and leaving the bacterium unable to synthesize proteins vital to its growth. It is effective against gram-negative bacteria, fungi and mycobacteria.
Application Notes
Amikacin is most often used for treating infections with multidrug resistant Gram negative bacteria such as Pseudomonas aeruginosa, Acinetobacter, and Enterobacter.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Antibiotic
SPECIFICATIONS
SKU: 02150342-CF
Base Catalog Number: 150342
Alternate Names: 1-N-[L(-)-4-Amino-2-hydroxy-butyryl] kanamycin A; O-3-Amino-3-deoxy-a -D-glucopyranosyl-(1 ---> 6)-O-6-amino-6-deoxy-a-D-glucopyranosyl-(1 ---> 4)]- N1 -(4-amino-2-hydroxy-1-oxobutyl)-2-deoxy-D-streptamine; Lukadin
Beilstein Registration No
: 1445422
Biochemical Physiological Actions
: Amikacin prevents bacterial protein synthesis by binding to the 30S ribosome subunit and inducing mRNA misreading. It interferes with the translocation of tRNA from the A-site to the P-site.
CAS
: #
37517-28-5
EC No
: 253-538-5
MDL No
: MFCD11045969
Melting Point
: 203-204 °C
Molecular Formula
: C
22
H
43
N
5
O
13
Molecular Weight
: 585.60
Optical Rotation: +100.5°
Potency
: ~900 µg/mg
PPE
: Eyeshields, Gloves,respirator filter
RTECS No
: WK1955000
Solubility
: Water Solubility185000 mg/L (at 25 °C)
Vapor Pressure
: 5.79X10-28 mm Hg at 25 deg C (est)
