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Amphotericin B
Key Features and Details
Amphotericin B
SYNONYMS: Amphomoronal; Amphotericine B; Amphozone; Fungilin; Fungisone; Fungizone
CAS: #
1397-89-3
MOLECULAR FORMULA: C47H73NO17
MOLECULAR WEIGHT: 924.091 g/mol
BEILSTEIN REGISTRY No.: 78342
EC No: 215-742-2
MDL No: MFCD00877763
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PRODUCT DESCRIPTION
Amphotericin B
Application Notes
Amphotericin B is used to study the affects of the influx of calcium on antifungal activity and to study the binding and kinetics of Amphotericin B to sterols in monolayers, aqueous solutions, and phospholipid bilayers . It is also commonly used in tissue culture as an antifungal supplement.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Antibiotic
SPECIFICATIONS
SKU: 02195043-CF
Base Catalog Number: 195043
Alternate Names: Amphomoronal; Amphotericine B; Amphozone; Fungilin; Fungisone; Fungizone
Beilstein Registration No
: 78342
Biochemical Physiological Actions
: Amphotericin B is a polyene antifungal antibiotic from Streptomyces. It has an affinity for sterols, primarily ergosterols, of fungal cell membranes. It forms channels in the membranes, causing small molecules to leak out which contributes to cell death. Antimicrobial spectrum: fungi and yeast. Polyene antifungal antibiotic from Streptomyces. Affinity for sterols, primarily ergosterols, of fungal cell membranes. Forms channels in the membranes, causing small molecules to leak out. Antimicrobial spectrum: fungi and yeast
CAS
: #
1397-89-3
EC No
: 215-742-2
Hazard Statements
: H315-H319-H335
MDL No
: MFCD00877763
Melting Point
: greater than 338° F (decomposes) (NTP, 1992)
Molecular Formula
: C47H73NO17
Molecular Weight
: 924.091 g/mol
pKa
: 5.5 and 10.0.(Lit.)
Potency
: >800 µg/mg
PPE
: dust mask , Eyeshields, Gloves
RTECS No
: BU2625000
Safety Symbol
: GHS07
Solubility
: less than 1 mg/mL at 70° F (NTP, 1992)
Source
: Streptomyces sp.
Sterilization of Solutions
: Sterilization of solutions should be by filtration through teflon membrane filters; Amphotericin B should not be gamma irradiated or autoclaved.
Typical Working Concentration
: recommended concentration of 2.5 ug/L (prepared solution use 10 mL/L)
