A bactericidal aminoglycoside antibiotic predominantly active against gram-negative bacteria. It disrupts protein synthesis at the 30S ribosome. Used as a selection agent (gentamicin-resistance gene) in cell culture and molecular biology applications. Approximately 600 µg gentamycin per mg.
Application Notes
Gentamicin sulfate is a broad spectrum antibiotic. It inhibits the growth of a wide variety of Gram-positive and Gram-negative microorganisms, including strains resistant to tetracycline, chloramphenicol, kanamycin, and colistin, particularly strains of Pseudomonas, Proteus, Staphylococcus, and Streptococcus. Gentamicin sulfate inhibits bacterial protein biosynthesis by binding to the 30S subunit of the ribosome.
Usage Statement
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