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Rifampin, phytopure
Key Features and Details
Number: 13292-46-1
SYNONYMS: Rifamycin AMP; Rifampicin; 3-(4-Methylpiperazinyliminomethyl)rifamycin SV; Rifampicin
CAS: #
13292-46-1
MOLECULAR FORMULA: C
43
H
58
N
4
O
12
MOLECULAR WEIGHT: 822.90
BEILSTEIN REGISTRY No.: 5723476
EC No: 236-312-0
MDL No: MFCD00151389
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PRODUCT DESCRIPTION
A bactericidal antibiotic drug of the rifamycin group. It specifically inhibits DNA-dependent bacterial RNA Polymerase. Mammalian RNA polymerase is not affected so it is useful in plant cell culture work. It is effective against mycobacteria. Also an inhibitor of chloroplast RNA polymerase and may be used to study chloroplast-level DNA transcription in plants.
Application Notes
Rifampicin is used to treat Tuberculosis and Tuberculosis-related mycobacterial infections. It is widely used as an antipruritic agent in the autoimmune cholestatic liver disease, primary biliary cirrhosis (PBC). It has been shown to cause hepatitis.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Antibiotic | Inhibitor of transcription initiation | Antipruritic agent
SPECIFICATIONS
SKU: 02195490-CF
Base Catalog Number: 195490
Alternate Names: Rifamycin AMP; Rifampicin; 3-(4-Methylpiperazinyliminomethyl)rifamycin SV; Rifampicin
Beilstein Registration No
: 5723476
Biochemical Physiological Actions
: Mode of Action: Inhibits initiation of RNA synthesis by binding to ß-subunit of RNA polymerase. It Inhibits the assembly of DNA and protein into mature virus particles.
CAS
: #
13292-46-1
EC No
: 236-312-0
Extinction Coefficient
: EmM (max absorbance, phosphate buffer,pH 7.38): 33.20 (237 nm); 32.10 (255 nm); 27.00 (334 nm);15.40 (475 nm)(Lit.)
Format
: Powder
Hazard Statements
: H302-H315-H319-H335
Isoelectric Point
: 4.8(in water)(Lit.)
MDL No
: MFCD00151389
Melting Point
: 183 °C
Molecular Formula
: C
43
H
58
N
4
O
12
Molecular Weight
: 822.90
Optical Rotation: [a]D25°=+10.6° (c=0.5% in CDCl3)(Lit.)
pKa
: pKa (in water):1.7 (4-hydroxyl group), 7.9 (4-piperazine nitrogen); in methylcellosolve-water (4:1): 3.6 (4-hydroxyl group), 6.7 (3-piperazine nitrogen)(Lit.)
PPE
: Dust mask, Eyeshields, Gloves
RTECS No
: VJ7000000
Safety Symbol
: GHS07
Solubility
:
Water Solubility
1400 mg/L (at 25 °C)UV Visible Absorbance
: ? max (methanol): 237 - 239, 334 - 338, 475 - 479 nm
Vapor Pressure
: 3.1X10-34 mm Hg at 25 deg C /Estimated/
