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Streptozotocin
Key Features and Details
Streptozotocin
SYNONYMS: N-(Methylnitrosocarbamoyl)-a-D-glucosamine; Streptozocin; STZ; 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose
CAS: #
18883-66-4
MOLECULAR FORMULA: C8H15N3O7
MOLECULAR WEIGHT: 265.222 g/mol
BEILSTEIN REGISTRY No.: 2060675
EC No: 242-646-8
MDL No: MFCD00006607
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PRODUCT DESCRIPTION
Streptozotocin
Application Notes
Streptozocin is used to induce Type 1 diabetes for medical research. It has been used for the treatment of malignant insulinoma It is used mainly in the treatment of pancreatic (islet-cell) tumors.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Treatment of pancreatic (islet-cell) tumors
SPECIFICATIONS
SKU: 02100557-CF
Base Catalog Number: 100557
Alternate Names: N-(Methylnitrosocarbamoyl)-a-D-glucosamine; Streptozocin; STZ; 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose
Beilstein Registration No
: 2060675
Biochemical Physiological Actions
: An N-nitroso-containing compound that acts as a nitric oxide donor in pancreatic islets; induces death of insulin-secreting cells, producing an animal model of diabetes. Potent DNA methylating agent that induces chromosomal breakage. Cytotoxic to neuroendocrine tumor cell lines that express the GLUT2 glucose transporter.
CAS
: #
18883-66-4
EC No
: 242-646-8
Extinction Coefficient
: EmM(228 nm): 6.36 (ethanol)
Format
: Powder
Half Life
: biological half-life in cell culture medium was shown to be approximately 19 minutes.
Hazard Statements
: H350
MDL No
: MFCD00006607
Melting Point
: 239° F (Decomposes) (NTP, 1992)
Molecular Formula
: C8H15N3O7
Molecular Weight
: 265.222 g/mol
PPE
: Eyeshields, full-face particle respirator type N100, Gloves, respirator cartridge, respirator filter
Purity
: ~75% a-anomer basis; =97%
RTECS No
: LZ5775000
Safety Symbol
: GHS06+GHS08
Solubility
: Soluble (NTP, 1992)
