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Tetracycline, hydrochloride
Key Features and Details
Tetracycline Hydrochloride
SYNONYMS: Achromycin HCl; Polucycline HCl; [4S-(4a, 4aa, 5aa, 6b, 12aa)]- 4-(Dimethylamino)- 1, 4, 4a, 5, 5a, 6-11, 12a-octahydro-3, 6, 10, 12, 12a-pentahydroxy- 6- methyl-1, 11-dioxo-2-naphthacenecarboxamide hydrochloride; Achro; Achromycin; Achromycin V; Ala Tet; Ambracyn; Ambramicina; Bristaciclina; Cefracycline; Criseociclina; Cyclopar; Diocyclin; Helvecyclin; Hostacyclin; Imex; Mediletten; Mephacyclin; Panmycin; Partrex; Polycycline; Purocyclina; Quadracyclin; Remicyclin; Riocyclin; Ro-Cycline; Sanclomycine; Steclin; Sumycin; Supramycin; Sustamycin; Tefilin; Tetrabakat; Tetrabid; Tetrablet; Tetrabon; Tetrachel; Tetracompren; Tetracyn; Tetrakap; Tetralution; Tetramavan; Tetramycin; Tetrosol; Topicycline; Totomycin; Triphacyclin; Unicin; Vetquamycin-324
CAS: #
64-75-5
MOLECULAR FORMULA: C22H24N2O8·HCl
MOLECULAR WEIGHT: 480.898 g/mol
BEILSTEIN REGISTRY No.: 3844873
EC No: 200-593-8
MDL No: MFCD00078142
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PRODUCT DESCRIPTION
Tetracycline Hydrochloride
Application Notes
Tetracycline is a broad spectrum polyketide antibiotic with clinical uses in treating bacterial infections such as Rocky Mountain spotted fever, typush fever, tick fevers, Q fever, and Brill-Zinsser disease and to treat upper respiratory infections and acne. It has been used in studies of multidrug resistance and potential side effects including acute pancreatitis.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
SPECIFICATIONS
SKU: 02103011-CF
Base Catalog Number: 103011
Alternate Names: Achromycin HCl; Polucycline HCl; [4S-(4a, 4aa, 5aa, 6b, 12aa)]- 4-(Dimethylamino)- 1, 4, 4a, 5, 5a, 6-11, 12a-octahydro-3, 6, 10, 12, 12a-pentahydroxy- 6- methyl-1, 11-dioxo-2-naphthacenecarboxamide hydrochloride; Achro; Achromycin; Achromycin V; Ala Tet; Ambracyn; Ambramicina; Bristaciclina; Cefracycline; Criseociclina; Cyclopar; Diocyclin; Helvecyclin; Hostacyclin; Imex; Mediletten; Mephacyclin; Panmycin; Partrex; Polycycline; Purocyclina; Quadracyclin; Remicyclin; Riocyclin; Ro-Cycline; Sanclomycine; Steclin; Sumycin; Supramycin; Sustamycin; Tefilin; Tetrabakat; Tetrabid; Tetrablet; Tetrabon; Tetrachel; Tetracompren; Tetracyn; Tetrakap; Tetralution; Tetramavan; Tetramycin; Tetrosol; Topicycline; Totomycin; Triphacyclin; Unicin; Vetquamycin-324
Beilstein Registration No
: 3844873
Biochemical Physiological Actions
: Mode of Action: Tetracycline passively diffuses through proin channels in the cell membrane, binding to 30S ribosomes and inhibits protein synthesis by preventing access of aminoacyl tRNA to the acceptor site on the mRNA-ribosome complex. It also binds to the bacterial 50S ribosomal subunit, altering the membrane and causing intracellular components to leak from bacterial cells. The inhibitory effects can be reversed by washing, suggesting that it is the reversibly bound antibiotic, and not the irreversibly bound drug, that is responsible for antibacterial action.Mode of Resistance: The effects are inactivated via a loss of cell wall permeability.Antimicrobial spectrum: Includes a wide range of antimicrobial activity against gram-positive and gram-negative bacteria.
CAS
: #
64-75-5
EC No
: 200-593-8
Extinction Coefficient
: EMm (220nm) = 13 (free base in 0.1 M HCl); EmM (268nm) = 18.04 (free base in 0.1 M HCl); EmM (355nm) = 13.32 (free base in 0.1 M HCl)(Lit.)
Format
: Powder
Hazard Statements
: H315-H319-H335
MDL No
: MFCD00078142
Melting Point
: 417° F (decomposes) (NTP, 1992)
Molecular Formula
: C22H24N2O8·HCl
Molecular Weight
: 480.898 g/mol
Optical Rotation: -239 ° to -258 ° (c=0.01, 0.1 N HCl)
pH
: 3.0-7.0 /saturated solution/
pKa
: (50% aq DMF): 8.3, 10.2 (Lit.)
Potency
: =900 µg/mg
PPE
: Dust mask, Eyeshields, Gloves
RTECS No
: QI9100000
Safety Symbol
: GHS07
Solubility
: 50 to 100 mg/mL at 72° F (NTP, 1992)
Typical Working Concentration
: 10 mg/L
UV Visible Absorbance
: ? max (1N HCl) 219, 271, 357 ± 5 nm
