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Wortmannin
Key Features and Details
Wortmannin
SYNONYMS: [1s-(1a,6ba,9ab,11a,11bb)]-11-(Acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-7,9,a,11b-dimethyl-3-furo (4,3,2-de)indeno[4,5,-h]-2-benzopyran-3,6,9-trione; KY 12420
CAS: #
19545-26-7
MOLECULAR FORMULA: C23H24O8
MOLECULAR WEIGHT: 428.437 g/mol
BEILSTEIN REGISTRY No.: 67676
MDL No: MFCD00133927
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PRODUCT DESCRIPTION
Wortmannin
Application Notes
Wortmannin is a commonly used cell biology reagent that has been used previously in research to inhibit DNA repair, receptor-mediated endocytosis and cell proliferation. It inhibits fMLP induced PIP3 and superoxide anion production in guinea pig neutrophils. It blocks insulin metabolic effects in rat adipocytes without affecting the insulin receptor tyrosine kinase activity.
Usage Statement
Unless specified otherwise, MP Biomedical's products are for research or further manufacturing use only, not for direct human use. For more information, please contact our customer service department.
Key Applications
Phosphatidylinositol 3-kinase (PI3-K) inhibitor
SPECIFICATIONS
SKU: 02195690-CF
Base Catalog Number: 195690
Alternate Names: [1s-(1a,6ba,9ab,11a,11bb)]-11-(Acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-7,9,a,11b-dimethyl-3-furo (4,3,2-de)indeno[4,5,-h]-2-benzopyran-3,6,9-trione; KY 12420
Beilstein Registration No
: 67676
Biochemical Physiological Actions
: Wortmannin is a potent and specific phosphatidylinositol 3-kinase (PI3-K) inhibitor. Inhibition of PI3-K/Akt signal transduction cascade enhances the apoptotic effects of radiation or serum withdrawal and blocks the antiapoptotic effect of cytokines. Inhibition of PI3-K by wortmannin also blocks many of the short-term metabolic effects induced by insulin receptor activation.
CAS
: #
19545-26-7
Format
: Powder
Hazard Statements
: H300-H310-H330
MDL No
: MFCD00133927
Molecular Formula
: C23H24O8
Molecular Weight
: 428.437 g/mol
PPE
: Eyeshields, Faceshields, full-face particle respirator, Gloves, respirator cartridge, respirator filter
RTECS No
: CB9641000
Safety Symbol
: GHS06
Source
: Penicillium wortmannii
