The NucleoSpin 96 Plasmid kits are designed for purifying up to 20 µg of high-copy plasmid from 1–5 ml of E. coli overnight culture, preferably grown in LB medium. The NucleoSpin Plasmid Binding Strips/Plates contain a unique silica membrane that binds DNA in the presence of chaotropic salt. 96-well plates can be processed manually (under vacuum or by centrifugation) or using automated liquid handlers.