The NucleoSpin RNA Blood and NucleoSpin RNA Blood Midi kits provide a simple, efficient, and direct total blood lysis method for isolating high-quality RNA from fresh or frozen whole blood that has been stabilized with anticoagulants (e.g., EDTA, citrate, or heparin). The entire procedure is performed at room temperature, with no need for selective erythrocyte lysis at 4°C (a common and cumbersome requirement for other methods).